Linus Pauling’s and Matthias Rath’s Unified Theory of Human Cardiovascular Disease (References)
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- 1 Milton, K. (1999) “Nutritional characteristics of wild primate foods: do the diets of our closest living relatives have lessons for us?” Nutrition. 1999 Jun;15(6):488-98. [back]
- 2 Favorable response when under 500 mg was administered:
- Khaw KT, et al. Interrelation of VITAMIN C, infection, haemostatic factors, and cardiovascular disease. BMJ 1995 Jun 17;310(6994):1559-63.
- 3 Favorable response when over 500 mg was administered:
- Gokce N, et al. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1999 Jun 29;99(25):3234-40.
- Chambers JC, et al. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin c therapy. Circulation 1999 Mar 9;99(9):1156-60.
- Wilkinson IB, et al. Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J Cardiovasc Pharmacol 1999 Nov;34(5):690-3.
- Jeserich M, et al. Vitamin C improves endothelial function of epicardial coronary arteries in patients with hypercholesterolaemia or essential hypertensionŒassessed by cold pressor testing. Eur Heart J 1999 Nov;20(22):1676-80.
- Frei B. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med 1999 Dec;222(3):196-204.
- Nappo F, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA 1999 Jun 9;281 (22):2113-8
- McAuliffe AV, et al. Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion. Nephron 1998 Nov;80(3):277-84.
- Solzbach U, et al. Circulation 1997 Sep 2;96(5):1513-9. Vitamin c improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients.
- Ting HH, et al. VITAMIN C improves endotheliumdependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 1997 Jun 17;95(12):2617-22.
- Mosca L, et al. Antioxidant nutrient supplementation reduces the susceptibility of low density lipoprotein to oxidation in patients with coronary artery disease. J Am Coll Cardiol 1997 Aug;30 (2):392-9.
- Levine GN, et al. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996 Mar 15;93(6):1107-13
- Fuller CJ, et al. Effect of ascorbate supplementation on low density lipoprotein oxidation in smokers. Atherosclerosis 1996 Jan 26;119(2):139-50.
- Valkonen MM, et al. Vitamin C prevents the acute atherogenic effects of passive smoking. Free Radic Biol Med 2000 Feb 1;28(3):428-36.
- Schwille PO, et al. Postprandial hyperinsulinaemia, insulin resistance and inappropriately high phosphaturia are features of younger males with idiopathic calcium urolithiasis: attenuation by Ascorbic acid supplementation of a test meal. Urol Res 1997;25(1):49-58.
- Zhang J, et al. A single high dose of vitamin C counteracts the acute negative effect on microcirculation induced by smoking a cigarette. Microvasc Res 1999 Nov;58(3):305-11.
- Purkayastha SS, et al. Effect of vitamin C and E in modulating peripheral vascular response to local cold stimulus in man at high altitude. Jpn J Physiol 1999 Apr;49(2):159-67.
- Chamiec T, et al. Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction. Am J Cardiol 1996 Feb 1;77(4):237-41.
- Weber C, et al. Increased adhesiveness of isolated monocytes to endothelium is prevented by VITAMIN C intake in smokers. Circulation 1996 Apr 15;93 (8):1488-92.
- Gatto LM, et al. Ascorbic acid induces a favorable lipoprotein profile in women. J Am Coll Nutr 1996 Apr;15(2):154-8.
Singh RB, et al. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian Experiment of infarct survival-3). Am J Cardiol 1996 Feb 1;77(4):232-6 - Munoz JA, et al. Effect of VITAMIN C on lipoproteins in healthy adults. Ann Med Interne (Paris) 1994;145(1):13-9.
Tomoda H, et al. Possible prevention of postangioplasty restenosis by Ascorbic acid. Am J Cardiol 1996 Dec 1;78(11):1284-6. - Laskowski H, et al. Mortality and clinical course of patients with acute myocardial infarction treated with streptokinase and antioxidants: mannitol and Ascorbic acid. Int J Cardiol 1995 Mar 3;48(3):235-7.
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Eriksson J, et al. Magnesium and Ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab 1995;39(4):217-23.
Gilligan DM, et al. Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia. J Am Coll Cardiol 1994 Dec;24(7):1611-7. - Cerna O, et al. Plasma lipids, lipoproteins and atherogenic index in men and women administered vitamin c. Cor Vasa 1992;34(3):246-54.
- Barta E, et al. Protective effect of alpha-tocopherol and L-ascorbic acid against the ischemic-reperfusion injury in patients during open-heart surgery. Bratisl Lek Listy 1991 Mar-Apr;92(3-4):174-83.
- Salonen JT, et al. Effects of antioxidant supplementation on platelet function: a randomized pairmatched, placebo-controlled, double-blind trial in men with low antioxidant status. Am J Clin Nutr 1991 May;53(5):1222-9.
Hornig B, et al. Vitamin c improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation 1998 Feb 3;97(4):363-8. - Heitzer T, et al. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 1996 Jul 1;94(1):6-9.
- 4 No response when under 500 mg was administered:
- Azen SP, et al. Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering. Circulation 1996 Nov 15;94(10):2369-72.
Mayer-Davis EJ, et al. Vitamin c intake and cardiovascular disease risk factors in persons with noninsulin-dependent diabetes mellitus. From the Insulin Resistanc Atherosclerosis Study and the San Luis Valley Diabetes Study. Prev Med 1997 May- Jun;26(3):277-83. - Calzada C, et al. The influence of antioxidant nutrients on platelet function in healthy volunteers. Atherosclerosis 1997 Jan 3;128(1):97-105.
- Azen SP, et al. Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering. Circulation 1996 Nov 15;94(10):2369-72.
- 5 No response when over 500 mg was administered:
- Bostom AG, et al. The effect of high-dose ascorbate supplementation on plasma lipoprotein(a) levels in patients with premature coronary heart Jacques PF, et al. Effect of VITAMIN C supplementation on lipoprotein cholesterol, apolipoprotein, and triglyceride concentrations. Ann Epidemiol 1995 Jan;5(1):52-9.
- Kelly TH, et al. Response patterns and cardiovascular effects during response sequence acquisition by humans. J Exp Anal Behav 1991 Nov;56(3):557-74. 71. Weber C, et al. Increased adhesiveness of isolated monocytes to endothelium is prevented by VITAMIN C intake in smokers. Circulation 1996 Apr 15;93 (8):1488-92.
- Westhuyzen J, et al. Effect of preoperative supplementation with alpha-tocopherol and ascorbic acid on myocardial injury in patients undergoing cardiac operations. J Thorac Cardiovasc Surg 1997 May;113 (5):942-8.
- 6 Linus Pauling’s work on vitamin C and cancer together with the British cancer surgeon, Ewan Cameron:
- Cameron, E. and Pauling, L. (1976) Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proceedings of the National Academy of Sciences USA. 73:3685-3689.
- Cameron, E. and Pauling, L. (1978) Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer. Proceedings of the National Academy of Sciences USA. 75:4538-4542
- Cameron E, Pauling L, Leibovitz B. (1979) Ascorbic acid and cancer: a review. Cancer Research 39, 663-681.
- Cameron E, Pauling L. Cancer and Vitamin C. Linus Pauling Institute of Science and Medicine, Menlo Park, Ca. (1979); (Weidenfeld and Nicholson, London 1980; Kyoritsu Shuppan KK, Tokyo 1981; Warner Books, New York 1981; Services Complet d’Editions, Quebec and Paris 1982).
- Cameron, E. and Pauling, L. (1973) Ascorbic acid and the glycosaminoglycans: An orthomolecular approach to cancer and other diseases. Oncology (Basel) 27: 181-192.
- Cameron E, Pauling L. Experimental studies designed to evaluate the management of patients with incurable cancer. Proc Natl Acad Sci USA 1978; 75:6252.
- Cameron E, Pauling L. (1979) Ascorbate and cancer. Proc. Am. Phil. Soc. 123:117-123.
- Cameron E, Pauling L (1978) Ascorbic acid as a therapeutic agent in cancer. J. Intern. Acad. Prev. Med. 5 (1), 8-29
- Cameron F, Pauling L. (1981) Survival times of terminal lung cancer patients treated with ascorbate. J. Intern. Acad. Prev. Med. 6: 21-27.
- Cameron E and Pauling L (1978) Ascorbic acid as a therapeutic agent in cancer. J. Intern. Acad. Prev. Med. 5 (1), 8-29.
- Cameron E and Pauling L (1980) On cancer and vitamin C. Executive Health 16 (4), 1-8. Jan.
- Cameron E and Pauling L (1981) Survival times of terminal lung cancer patients treated with ascorbate. J. Intern. Acad. Prev. Med. 6) 21-27.
- Cameron E and Pauling L (1982) Megadoses of vitamin C as an adjunct in the treatment of cancer. Your Patient and Cancer 2, 39-46. May.
- Pauling L and Cameron E (1983) Vitamin C and cancer. Australasian Health & Healing 2 (3), 9-10 (April-June).
- Cameron, Ewan (Undated, c.1986-88) Protocol for the use of intravenous vitamin C in the treatment of cancer. Linus Pauling Institute of Science and Medicine, Palo Alto, California. 8 pp.
- Cameron E and Pauling L (1987) Vitamin C and AIDS. Washington Post Health, p. 4. Feb. 3.
- Cameron, E. and Pauling, L. (1993) Cancer and Vitamin C, revised edition. Philadelphia: Camino Books.
- 7 Creagan ET, Moertel CG, O’Fallon JR, et al. Failure of high-dose vitamin C therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 1979;301:687–90. [back]
- 8 Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12. [back]
- 9 Sebastian J. Padayatty and others. Vitamin C documented to quell advanced-stage cancer in three cases involving bladder, lung, kidney and lymphoma tumors. Canadian Medical Assn Journal 174: 937–42, 2006
The study underwent rigorous case reporting standards as outlined by the U.S. National Cancer Institute. [back] - 10 FDA OK’s vitamin C trial for cancer. Physorg.com (January 12, 2007). “Federal approval of a clinical trial on intravenous vitamin C as a cancer treatment lends credence to alternative cancer care, U.S. researchers said.” [back]
Posted: June 30th, 2009 at 09:02 →
Ascorbic acid does a lot of things inside and outside the body. It boosts the immune system, protects the cells from free radical damage and it also smooths out the texture of the skin when used topically. I see to eat that i get my daily Vitamin-C from natural fruits juices plus ascorbic acid supplements.